Contents:

1. Principles of nuclear magnetic resonance. Magnetic properties of nuclei, resonance signal genesis, nuclear shielding and chemical shift, spin-spin interaction, relaxation mechanisms, NMR signal intensities.
2. NMR spectrometer - Basic components, types of construction, measurement techniques. Fourier transform Double resonance. Measurement of relaxation times. Solvent signal suppression.
3.Sample preparation, solvents, standards.
4. 1H-NMR techniques.
5. 13C-NMR techniques.
6. 15N, 18F, 31P, 2H, 3H and other measurement techniques.
7. Special NMR techniques. 2D-NMR (COSY, NOESY, TOCSY, HETCOR), solid-state NMR (MAS).
8. Interpretation of spectral data: 1H, 13C, 15N, 31P, special techniques 3H/2H
9. Interpretation and measurements of APT, DEPT, COESY, NOESY, TOCSY, HQMBC isotopic composition manifestations
10. Application of NMR.

Recommended literature:

Key Literature:
1. Gunther H.: NMR Spectroscopy: Basic Principles, Concepts and Applications in Chemistry. Willey 2013.
Recommended Literature:
1. Williams D.H., Fleming I.: Spectroscopic methods in organic chemistry. 5th eddition.

Keywords:

NMR spectrometry

Abbreviations used:

Semester:

• W ... winter semester (usually October - February)
• S ... spring semester (usually March - June)
• W,S ... both semesters

Mode of completion of the course:

• A ... Assessment (no grade is given to this course but credits are awarded. You will receive only P (Passed) of F (Failed) and number of credits)
• GA ... Graded Assessment (a grade is awarded for this course)
• EX ... Examination (a grade is awarded for this course)
• A, EX ... Examination (the award of Assessment is a precondition for taking the Examination in the given subject, a grade is awarded for this course)

Weekly load (hours per week):

• P ... lecture
• C ... seminar
• L ... laboratory
• R ... proseminar
• S ... seminar