Description:

Introduction to the second group of organic compounds, carboxylic acids and their derivatives, heterocyclic compounds, important natural compounds, industrial organic compounds and pharmaceuticals - industrial and natural. Introduction to the metods of structural analysis.

Contents:

1. 1. Carboxylic acids ? nomenclature, structure, properties, methods of preparation.
2. Carboxylic acids ? reactivity. Dicarboxylic acids, methods of preparation, their reactions.
3. Substituted carboxylic acids ? preparation, properties.
4. Halogen-, hydroxy-, oxo- and amino- acids ? nomenclature, structure, preparation, reactivity.
5. Functional derivatives of carboxylic acids ? nomenclature, structure, preparation, reactivity.
6. Esters ? condensation reactions, use in syntheses.
7. Derivatives of carbonic acid, carbamates, nitriles, isonitriles, ketenes, isocyanates, carbodiimides.
8. Heterocyclic compounds ? characterization, properties, preparation, reactivity.
9. Natural compounds ? sacharides, terpenes, steroid hormons - nomenclature, structure, properties.
10. Natural compounds ? lipides, alkaloids, secondary plant metabolites
11. Industrial organic compounds, tenzides, pesticides, pharmaceuticals.
12. Metods of structural analysis of organic compounds, basics of spectral methods.

Seminar contents:

1. Preparation and reactions of carboxylic acids.
2. Halogen-, hydroxy-, oxo-, amino- acids and their derivatives ? nomenclature, propeties, preparation and reactions.
3. Esters ? preparation, reactions and use in organic synthesis.
4. Preparation and reactions of carbonic acid derivatives.
5. Preparation, reactions and properties of heterocyclic compounds.
6. Natural compounds ? nomenclature, structure, occurence, preparation and reactions, use.
7. Industrial organic compounds ? types, use, preparation, specificity of reactions in laboratory and industrial scale.
8. Pharmaceuticals production ? history, current demands, examples of syntheses, research and development of pharmaceuticals.
9. Basics of organic compounds structural analysis, spectral methods, principles of compounds identification.
10. Identification of simple organic compounds based on provided spectral data, NMR, MS, IR methods.

Recommended literature:

Compulsory literature:
Smrček S., Kozempel J.: Electronic presentation Organic chemistry course, available on FNSPE website.

Other recommended literature:
McMurry J.: Organic chemistry, Brooks/Cole Cengage Learning, ISBN 9780534389994.
Lewis D.E. Organic Chemistry ? a Modern Perspective, Times Mirror Education Group, Inc. Dubunque 1996, ISBN0697350916.

Keywords:

organic chemistry, natural compounds, pharmaceuticals

Abbreviations used:

Semester:

• W ... winter semester (usually October - February)
• S ... spring semester (usually March - June)
• W,S ... both semesters

Mode of completion of the course:

• A ... Assessment (no grade is given to this course but credits are awarded. You will receive only P (Passed) of F (Failed) and number of credits)
• GA ... Graded Assessment (a grade is awarded for this course)
• EX ... Examination (a grade is awarded for this course)
• A, EX ... Examination (the award of Assessment is a precondition for taking the Examination in the given subject, a grade is awarded for this course)

Weekly load (hours per week):

• P ... lecture
• C ... seminar
• L ... laboratory
• R ... proseminar
• S ... seminar