Description:

In the first part, the sources of ionizing radiation (IR) used in biology and medicine are thoroughly discussed. Description of interaction of IR with matter and influence of ionizing radiation on biologically important structures and organisms follows. The last part of the course is dedicated to theory of radiobiological action, radiodiagnostic and radiotherapeutical methods, safeguard and dozimetry.

Contents:

1.Description and comparison of irradiation sources utilized in radiation biological and radiation medicinal applications.
2.Radiolysis of water and selected inorganic compounds in water solutions.
3.Structural units of living organisms.
4.Influence of ionizing radiaton on glycides, lipides, amino acids, proteins, vitamins, ferments, hormones, nucleic acids.
5.Characterization of biological effects of individual types of ionizing radiation.
6.Effects of irradiation on chemical processes in living organisms.
7.Theory of radiobiological action, reparation processes.
8.Effect of irradiation on cells of simple and complex organisms, mutual comparison.
9.Effects of irradiation on humans, radiotherapeutical methods.
10.Imaging and radiodiagnostic methods.
11.Overview of basic calculations in radiation medicine and biology.
12.Safeguard, dozimetric measuements.

Recommended literature:

Key Literature:
1. V. Čuba: Radiation Methods in Biology and Medicine, set of teaching materials, Praha, 2018
2. J. F. Wishart, B. S. M. Rao (eds): Recent trends in Radiation Chemistry, World Scientific Publishing, London, 2010
3. W. H. Scharf: Biomedical Particle Accelerators, AIP Press, New York, 1994
Recommended Literature:
1. Farhataziz, M. A. J. Rodgers (eds): Radiation Chemistry - Principles and Applications, VCH Publishers, Inc., New York, 1987
2. V. Arena: Ionizing Radiation and Life: An Introduction to Radiation Biology and Biological Radiotracer Methods, Mosby, Saint Louis, 1971

Keywords:

Radiation chemistry, ionising radiation, radiolysis, radiobological action, radiodiagnostics, radiotherapy

Abbreviations used:

Semester:

• W ... winter semester (usually October - February)
• S ... spring semester (usually March - June)
• W,S ... both semesters

Mode of completion of the course:

• A ... Assessment (no grade is given to this course but credits are awarded. You will receive only P (Passed) of F (Failed) and number of credits)
• GA ... Graded Assessment (a grade is awarded for this course)
• EX ... Examination (a grade is awarded for this course)
• A, EX ... Examination (the award of Assessment is a precondition for taking the Examination in the given subject, a grade is awarded for this course)

Weekly load (hours per week):

• P ... lecture
• C ... seminar
• L ... laboratory
• R ... proseminar
• S ... seminar