Description:

The lecture gives a comprehensive survey of toxicology of chemicals. It deals with general and special toxicology, legislation and work safety in chemical laboratory. Several selected chapters are devoted to analytical and predictive toxicology. General toxicology explains toxic indices, their determination and interpretation, hazard and risk, mechanisms of absorption, distribution, biotransformation and elimination of chemicals in a body, mechanisms of toxic effects and factors governing these effects. Physicochemical and biochemical interpretation of toxic actions is stressed.

Contents:

1. General toxicology ? basic nomeclature.
2. Biology, physiology; mechanisms of absorption and distribution of chemicals.
3. Biotransformation and elimination of chemicals.
4. Mechanisms of basic toxic effects; factors determining toxicity; toxicological indexes.
5. Experimental toxicology.
6. Qualitative and quantitative relationships between chemical structure and biological effects of chemicals.
7. Toxicology of inorganic compounds.
8. Toxicology of organic and organometallic compounds.
9. Analytical toxicology, ecotoxicology and prediction toxicology.
10. Legislation and interpretation of European law - REACH. 11. Safety work and hygiene in chemical laboratory

Recommended literature:

Casaret & Doull?s Toxicology. The Basic Science of Poisons. 6th Ed. New York, McGrawHill 2001.
A Textbook of Modern Toxicology. 3rd Ed. Edited by Ernest Hodgson. New York, Wiley 2006.

Keywords:

toxicology, poisons, hazardous materials

Abbreviations used:

Semester:

• W ... winter semester (usually October - February)
• S ... spring semester (usually March - June)
• W,S ... both semesters

Mode of completion of the course:

• A ... Assessment (no grade is given to this course but credits are awarded. You will receive only P (Passed) of F (Failed) and number of credits)
• GA ... Graded Assessment (a grade is awarded for this course)
• EX ... Examination (a grade is awarded for this course)
• A, EX ... Examination (the award of Assessment is a precondition for taking the Examination in the given subject, a grade is awarded for this course)

Weekly load (hours per week):

• P ... lecture
• C ... seminar
• L ... laboratory
• R ... proseminar
• S ... seminar