Code: 15TOXA Toxicology
Lecturer: doc. RNDr. Ján Kozempel Ph.D. Weekly load: 2P Completion: EX
Department: 14115 Credits: 2 Semester: S
Description:
Overview of basic toxicology, containing general and special toxicology, toxicological data, legislation and basic aspects of chemical compounds handling. In general toxicology aspects of toxicity, metabolism, biodistribution and elimination has been described, as well as toxicological effects, evaluation of toxicity, indexes, and biological tests. In special toxicology part selected group of organic compounds, inorganic compounds, natural compounds and warfare were described from toxicity behaviour. In legislation part REACH, international and national regulation is described.
Contents:
1. General toxicology, basic terminology.
2. Biology, physiology, mechanism of uptake and distribution.
3. Biotransformation and elimination of xenobiotics.
4. Basic toxicology effects, factor, indexes.
5. Experimental toxikology.
6. Quantitative and qualitative relation between structure and biological effects.
7. Toxicology of inorganic compounds.
8. Toxicology of organic compounds and organometals.
9. Analytical and predictive toxicology, ecotoxicology.
10. Legislation and regulation, REACH.
11. Basic safety standards in chemical laboratory.
Recommended literature:
Key Literature:
1. Selected articles in Toxicology, Elsevier Journal, 2000-2019
2. E. Hodgson (Ed.): A Textbook of Modern Toxicology, 4nd Ed., New York, Wiley, 2010
Recommended Literature:
3. C. Klaassen: Casarett & Doull?s Toxicology: The Basic Science of Poisons, 8th Ed, New York, McGrawHill, 2013
Keywords:
Toxicology, poisons, hazardous materials.

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